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Share-Based Compensation (Tables)
3 Months Ended
Mar. 31, 2023
Share-Based Payment Arrangement [Abstract]  
Summary of Stock Award Activity for the Period
The following table summarizes the activity related to the stock option awards for the three months ended March 31, 2023:
Number of Shares Weighted
Average Exercise Price
Awards outstanding at December 31, 20228,418,571 $2.17 
Granted726,868 0.91 
Forfeited(50,000)1.29 
Awards outstanding at March 31, 20239,095,439 $2.07 
Options exercisable at March 31, 20233,500,344 $3.88 
Weighted average remaining contractual term6.3 Years
Options vested and expected to vest at March 31, 20236,963,039 $2.42 
Weighted average remaining contractual term7.7 Years
Summary of Compensation Expense Related to Grants of Stock Options
Compensation expense related to the grants of stock options is included in research and development and general and administrative expense as follows (in thousands):
Three Months Ended March 31,
20232022
Research and development$98 $92 
General and administrative245 384 
Total share-based compensation expense$343 $476