<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0306</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2019-08-22</periodOfReport>

    <issuer>
        <issuerCik>0001641489</issuerCik>
        <issuerName>vTv Therapeutics Inc.</issuerName>
        <issuerTradingSymbol>VTVT</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001186472</rptOwnerCik>
            <rptOwnerName>PERELMAN RONALD O</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O MACANDREWS &amp; FORBES INCORPORATED</rptOwnerStreet1>
            <rptOwnerStreet2>35 EAST 62ND STREET</rptOwnerStreet2>
            <rptOwnerCity>NEW YORK</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10065</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isTenPercentOwner>true</isTenPercentOwner>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Class A common stock</value>
            </securityTitle>
            <transactionDate>
                <value>2019-08-22</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>P</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>50000</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>1.38</value>
                    <footnoteId id="F1"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>21688714</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See footnote</value>
                    <footnoteId id="F2"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">The price reported in Column 4 is a weighted average price. These shares were acquired in multiple transactions at prices ranging from $1.365 to $1.40, inclusive. The reporting person undertakes to provide to vTv Therapeutics Inc. (the &quot;Issuer&quot;), any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the range set forth in this footnote to this Form 4.</footnote>
        <footnote id="F2">The ROP Revocable Trust dated 1/9/2018 (the &quot;ROP Revocable Trust&quot;), of which Mr. Ronald O. Perelman is the sole trustee and sole beneficiary, is the sole stockholder of MacAndrews &amp; Forbes Incorporated (&quot;M&amp;F Inc.&quot;), which is the parent of MFV Holdings One LLC (&quot;MFV&quot;) and MacAndrews &amp; Forbes LLC (&quot;M&amp;F LLC&quot;), which is the parent of M&amp;F Group. M&amp;F Group and MFV hold the securities described above. Mr. Perelman, the ROP Revocable Trust, M&amp;F Inc., M&amp;F LLC, M&amp;F Group and MFV may be deemed to be directors by deputization of vTv Therapeutics Inc. (the &quot;Issuer&quot;) by virtue of their relationship with Steven M. Cohen and Paul G. Savas, directors of the Issuer, and certain rights of M&amp;F TTP Holdings Two LLC, an indirect subsidiary of M&amp;F Inc. (&quot;M&amp;F TTP&quot;), pursuant to the Investor Rights Agreement, dated as of July 29, 2015, between the Issuer and M&amp;F TTP, as successor in interest to vTv Therapeutics Holdings LLC.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Ronald O. Perelman</signatureName>
        <signatureDate>2019-08-22</signatureDate>
    </ownerSignature>
</ownershipDocument>
