<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0306</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2019-03-18</periodOfReport>

    <issuer>
        <issuerCik>0001641489</issuerCik>
        <issuerName>vTv Therapeutics Inc.</issuerName>
        <issuerTradingSymbol>VTVT</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001186472</rptOwnerCik>
            <rptOwnerName>PERELMAN RONALD O</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O MACANDREWS &amp; FORBES INCORPORATED</rptOwnerStreet1>
            <rptOwnerStreet2>35 EAST 62ND STREET</rptOwnerStreet2>
            <rptOwnerCity>NEW YORK</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10065</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isTenPercentOwner>true</isTenPercentOwner>
        </reportingOwnerRelationship>
    </reportingOwner>

    <derivativeTable>
        <derivativeTransaction>
            <securityTitle>
                <value>Call Option (right to buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>1.65</value>
            </conversionOrExercisePrice>
            <transactionDate>
                <value>2019-03-18</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>J</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
                <footnoteId id="F1"/>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>1</value>
                </transactionShares>
                <transactionPricePerShare>
                    <footnoteId id="F1"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <exerciseDate>
                <value>2019-03-18</value>
            </exerciseDate>
            <expirationDate>
                <value>2020-03-18</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Class A common stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>5454545</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>1</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See footnote</value>
                    <footnoteId id="F2"/>
                </natureOfOwnership>
            </ownershipNature>
        </derivativeTransaction>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">On March 18, 2019, MacAndrews &amp; Forbes Group LLC (&quot;M&amp;F Group&quot;) entered into a letter agreement (the &quot;Letter Agreement&quot;), with vTv Therapeutics Inc. (the &quot;Issuer&quot;), for M&amp;F Group's commitment to purchase, at the Issuer's option, exercisable on demand during a one-year period after the date of the Letter Agreement (the &quot;Investment Period&quot;), the Company's Class A common stock, par value $0.01 per share (&quot;Common Stock&quot;) at a per share price of $1.65.  The Letter Agreement also permits M&amp;F Group to exercise an option to purchase Common Stock at the same price up to three times during the Investment Period.  The aggregate amount of Common Stock that may be purchased by M&amp;F Group (whether at its or the Issuer's option) pursuant to the Letter Agreement is limited to $9.0 million.</footnote>
        <footnote id="F2">The ROP Revocable Trust dated 1/9/2018 (the &quot;ROP Revocable Trust&quot;), of which Mr. Ronald O. Perelman is the sole trustee and sole beneficiary, is the sole stockholder of MacAndrews &amp; Forbes Incorporated (&quot;M&amp;F Inc.&quot;), which is the parent of MFV Holdings One LLC (&quot;MFV&quot;) and MacAndrews &amp; Forbes LLC (&quot;M&amp;F LLC&quot;), which is the parent of M&amp;F Group. M&amp;F Group and MFV hold the securities described above. Mr. Perelman, the ROP Revocable Trust, M&amp;F Inc., M&amp;F LLC, M&amp;F Group and MFV may be deemed to be directors by deputization of the Issuer by virtue of their relationship with Steven M. Cohen and Paul G. Savas, directors of the Issuer, and certain rights of M&amp;F TTP Holdings Two LLC, an indirect subsidiary of M&amp;F Inc. (&quot;M&amp;F TTP&quot;), pursuant to the Investor Rights Agreement, dated as of July 29, 2015, between the Issuer and M&amp;F TTP, as successor in interest to vTv Therapeutics Holdings LLC.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Ronald O. Perelman</signatureName>
        <signatureDate>2019-03-19</signatureDate>
    </ownerSignature>
</ownershipDocument>
