STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021
CASH FLOWS FROM OPERATING ACTIVITIES:
Net loss	$ (88,098)	$ (98,591)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	1,666	1,193
Stock-based compensation expense	9,576	8,500
Accretion of premium/discount on marketable securities	184	2,654
Loss on disposal of property and equipment		108
Change in fair value of convertible preferred stock purchase right liability		6,084
Non-cash lease expense	3,225	2,479
Changes in operating assets and liabilities:
Prepaid expenses and other assets	(903)	(568)
Accounts payable and accrued expenses	2,768	6,676
Operating lease liabilities	(2,596)	(1,179)
Deferred revenue	(2,162)	15,574
Other long-term liabilities	(164)	4
Net cash used in operating activities	(76,504)	(57,066)
CASH FLOWS FROM INVESTING ACTIVITIES:
Purchase of property and equipment	(1,953)	(2,338)
Purchases of marketable securities	(180,704)	(313,375)
Maturities of marketable securities	240,519	83,512
Net cash provided by (used in) investing activities	57,862	(232,201)
CASH FLOWS FROM FINANCING ACTIVITIES:
Proceeds from issuance of preferred stock, net		51,902
Proceeds from initial public offering, net of issuance cost		244,316
Proceeds from issuance of common stock related to stock purchase agreement		13,638
Proceeds from issuance of common stock	503	1,252
Net cash provided by financing activities	503	311,108
Net increase (decrease) in cash	(18,139)	21,841
Cash, cash equivalents and restricted cash at beginning of year	28,948	7,107
Cash, cash equivalents and restricted cash at end of period	10,809	28,948
Reconciliation of cash, cash equivalents and restricted cash:
Cash and cash equivalents	9,244	27,383
Restricted cash	1,565	1,565
Total cash, cash equivalents and restricted cash	10,809	28,948
Supplemental schedule of non-cash investing and financing activities:
Vesting of unvested issued common stock	4	123
Purchases of property and equipment included in accounts payable and accrued liabilities	8	1,021
Deferred offering costs in accounts payable and accrued liabilities	102
Right of use assets obtained in exchange for operating lease obligations	$ 852	$ 14,657