X0306 4 2020-02-05 0001267565 COLLEGIUM PHARMACEUTICAL, INC COLL 0001640701 Fleming Alison B C/O COLLEGIUM PHARMACEUTICAL, INC. 100 TECHNOLOGY CENTER DRIVE STOUGHTON MA 02072 0 1 0 0 Chief Technology Officer Common Stock 2020-02-05 4 A 0 22500 0 A 95842 D Common Stock 2020-02-05 4 A 0 18616 0 A 114458 D Stock Option (Right to Purchase) 21.34 2020-02-05 4 A 0 25000 0 A 2030-02-05 Common Stock 25000 25000 D Reflects the grant of restricted stock units. Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock. Twenty-five percent (25%) of the restricted stock units vest on February 10, 2021, and the balance of the restricted stock units vest in equal annual installments over the following three-year period, subject to the reporting person's continued service with the issuer. The restricted stock units will be settled on each applicable vesting date in shares of the issuer's common stock. Reflects the grant of restricted stock units. Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock. The restricted stock units vest on April 1, 2021, subject to the reporting person's continued service with the issuer. The restricted stock units will be settled on the vesting date in shares of the issuer's common stock. Twenty-five percent (25%) of the option vests and becomes exercisable on February 10, 2021, and the balance vests in equal quarterly installments (rounded up to the nearest whole share of common stock) over the following three-year period, subject to the reporting person's continued service with the issuer. /s/ Paul Brannelly as Attorney-In-Fact For Alison B. Fleming 2020-02-07