Significant agreements (Details) - USD ($) $ in Thousands	3 Months Ended
Mar. 31, 2025	Mar. 31, 2024
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Collaboration revenue	$ 6,473	$ 19,516
Related party collaboration receivables, beginning balance	676
Related party collaboration receivables, ending balance	487
2019 and 2023 Neurocrine Collaboration Agreement
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Related party collaboration receivables, beginning balance	676
Additions	385
Deductions	(574)
Related party collaboration receivables, ending balance	487
Deferred revenue, beginning balance	30,397
Deductions	(4,542)
Deferred revenue, ending balance	25,855
Discovery program 3 \| Neurocrine \| 2019 and 2023 Neurocrine Collaboration Agreement
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Additions	$ 4,500

Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

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