Related-party transactions (Details) - USD ($)	12 Months Ended
	Dec. 31, 2024	Dec. 31, 2023	Dec. 31, 2022
Related-party transactions
Related party collaboration receivable	$ 676,000	$ 3,341,000
Dr. Sah | Related Party
Related-party transactions
Total amount of services received	700,000	700,000	$ 500,000
Dr. Sandrock | Related Party
Related-party transactions
Total amount of services received			$ 60,000
Neurocrine Collaborative Agreement 2019 | Neurocrine | Related Party | Collaboration arrangement
Related-party transactions
Related party collaboration receivable	700,000	3,300,000
Neurocrine Collaborative Agreement 2023 | Neurocrine
Related-party transactions
Related party collaboration receivable	300,000	1,800,000
Neurocrine Collaborative Agreement 2023 | Neurocrine | Related Party | Collaboration arrangement
Related-party transactions
Related party collaboration receivable	$ 700,000	$ 3,300,000