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Stock-based compensation (Details) - shares	1 Months Ended	12 Months Ended			108 Months Ended
Stock-based compensation (Details) - shares	Oct. 31, 2015	Dec. 31, 2024	Dec. 31, 2023	Dec. 31, 2022	Dec. 31, 2024	Jan. 31, 2014
Stock-based compensation
Shares available for future issuance (in shares)		16,226,436	14,550,002		16,226,436
Stock options granted (in shares)		2,407,326
2014 Stock Option and Grant Plan
Stock-based compensation
Number of shares authorized for stock-based compensation plan (in shares)						823,529
2015 Employee Stock Purchase Plan
Stock-based compensation
Number of shares authorized for stock-based compensation plan (in shares)	262,362
Shares available for future issuance (in shares)		2,010,897			2,010,897
Percentage of outstanding common stock					1.00%
Common stock shares authorized for issuance					3,132,873
Period to purchase shares		6 months
New stock options issued		148,069	111,639
2015 Employee Stock Purchase Plan \| Minimum
Stock-based compensation
Percentage of payroll deduction	1.00%
2015 Employee Stock Purchase Plan \| Maximum
Stock-based compensation
Percentage of payroll deduction	10.00%
2015 Stock Option Plan
Stock-based compensation
Shares available for future issuance (in shares)	1,311,812	3,765,132	3,572,195		3,765,132
Percentage limit of issued and outstanding shares up to which additional shares may be issued	4.00%
Percentage of outstanding common stock					4.00%
Common stock shares authorized for issuance					14,717,369
Employee Stock Option
Stock-based compensation
Shares available for future issuance (in shares)		8,800,464	7,425,444		8,800,464
Employee Stock Option \| Inducement Awards
Stock-based compensation
Vesting period		4 years
Employee Stock Option \| Inducement Awards \| Vesting period, tranche one
Stock-based compensation
Vesting percentage		25.00%
Employee Stock Option \| Inducement Awards \| Vesting period, tranche two
Stock-based compensation
Vesting period		36 months
Vesting percentage		75.00%
Unvested restricted common stock units
Stock-based compensation
Vesting period		3 years
Shares available for future issuance (in shares)		1,649,943	1,370,897		1,649,943
Unvested restricted common stock units \| Inducement Awards
Stock-based compensation
Vesting period		3 years
New stock options issued		223,000	318,500	163,000
Unvested restricted common stock units \| Inducement Awards \| Vesting period, tranche one
Stock-based compensation
Vesting percentage		33.00%
Unvested restricted common stock units \| Inducement Awards \| Vesting period, tranche two
Stock-based compensation
Vesting percentage		33.00%
Founders restricted stock
Stock-based compensation
Shares available for future issuance (in shares)			22,500
Non-statutory stock options \| Inducement Awards
Stock-based compensation
New stock options issued		486,000	573,000	390,000
Employees and directors stock options \| 2014 Stock Option and Grant Plan
Stock-based compensation
Vesting period		4 years
Employees and directors stock options \| 2014 Stock Option and Grant Plan \| Vesting period, tranche one
Stock-based compensation
Vesting period		1 year
Vesting percentage		25.00%
Employees and directors stock options \| 2014 Stock Option and Grant Plan \| Vesting period, tranche two
Stock-based compensation
Vesting period		3 years
Vesting percentage		75.00%
Employees and directors stock options \| 2015 Stock Option Plan
Stock-based compensation
Stock options granted (in shares)		1,921,326
Non-employees stock options \| 2014 Stock Option and Grant Plan \| Minimum
Stock-based compensation
Vesting period		1 year
Non-employees stock options \| 2014 Stock Option and Grant Plan \| Maximum
Stock-based compensation
Vesting period		4 years