Property and equipment, net (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2024	Dec. 31, 2023	Dec. 31, 2022
Property, Plant and Equipment [Line Items]
Total property and equipment	$ 30,272	$ 31,532
Less: accumulated depreciation	(15,958)	(15,038)
Property and equipment, net	14,314	16,494
Depreciation expense	4,731	4,441	$ 6,191
Laboratory equipment
Property, Plant and Equipment [Line Items]
Total property and equipment	20,339	20,536
Leasehold improvements
Property, Plant and Equipment [Line Items]
Total property and equipment	6,487	7,106
Furniture and office equipment
Property, Plant and Equipment [Line Items]
Total property and equipment	2,334	2,625
Other
Property, Plant and Equipment [Line Items]
Total property and equipment	$ 1,112	$ 1,265