Significant Agreements - Neurocrine Collaboration receivables and contract liabilities (Details) $ in Thousands	9 Months Ended
	Sep. 30, 2024 USD ($)
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Related party collaboration receivables, beginning balance	$ 3,341
Related party collaboration receivables, ending balance	3,714
2023 Neurocrine Collaborative Agreement and 2019 Neurocrine Collaborative Agreement
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Related party collaboration receivables, beginning balance	3,341
Additions	11,895
Deductions	(11,522)
Related party collaboration receivables, ending balance	3,714
Deferred revenue, beginning balance	75,240
Additions	1,592
Deductions	(42,050)
Deferred revenue, ending balance	34,782
Discovery program 3 | Neurocrine | 2023 Neurocrine Collaborative Agreement and 2019 Neurocrine Collaborative Agreement
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Additions	1,600
Deductions	$ (42,100)