Significant Agreements - Neurocrine Collaboration Agreements (Details) $ in Thousands	1 Months Ended	3 Months Ended			6 Months Ended
	Apr. 30, 2024 USD ($)	Jun. 30, 2024 USD ($)	Mar. 31, 2024 USD ($)	Jun. 30, 2023 USD ($)	Jun. 30, 2024 USD ($) agreement	Jun. 30, 2023 USD ($)
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Number of new agreements | agreement					0
Collaboration revenue		$ 29,578		$ 4,853	$ 49,094	$ 155,333
2019 Neurocrine Collaborative Agreement | Neurocrine
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Milestone payments received			$ 5,000
Allocation of transaction price			5,000
Cumulative catch up of revenue recognized			$ 4,400
2023 Neurocrine Collaborative Agreement
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Milestone payments	$ 3,000
Revenue from contract with customer		$ 3,000