Significant Agreements - Neurocrine Collaboration Agreements (Details) $ in Thousands	3 Months Ended		12 Months Ended
	Mar. 31, 2024 USD ($) agreement	Mar. 31, 2023 USD ($)	Dec. 31, 2023 USD ($)
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Number of new agreements | agreement	0
Collaboration revenue	$ 19,516	$ 150,480	$ 150,500
2019 Neurocrine Collaborative Agreement | Neurocrine
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Milestone payments received	5,000
Allocation of transaction price	5,000
Cumulative catch up of revenue recognized	4,400
2023 Neurocrine Collaborative Agreement | Neurocrine
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Revenue recognized	$ 7,300