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Related party transactions (Details)	12 Months Ended
Related party transactions (Details)	Dec. 31, 2023 USD ($) item	Dec. 31, 2022 USD ($) item	Dec. 31, 2021 USD ($) item
Related party transactions
Related party collaboration receivable	$ 3,341,000	$ 257,000
Former Executives \| Related Party \| Board and scientific advisory services
Related party transactions
Number of individuals providing services \| item	1	1	1
Dr. Sah \| Related Party \| Board and scientific advisory services
Related party transactions
Total amount of services received	$ 700,000	$ 500,000	$ 200,000
Dr. Sandrock \| Related Party \| Consulting and advisor services
Related party transactions
Total amount of services received		$ 60,000
Neurocrine \| Related Party \| Collaboration arrangement
Related party transactions
Related party collaboration receivable	$ 3,300,000