Property and equipment, net (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022	Dec. 31, 2021
Property, Plant and Equipment [Line Items]
Property and equipment, gross	$ 31,532	$ 35,064
Less: accumulated depreciation	(15,038)	(17,207)
Property and equipment, net	16,494	17,857
Depreciation expense	4,441	6,191	$ 5,165
Laboratory equipment
Property, Plant and Equipment [Line Items]
Property and equipment, gross	20,536	19,675
Leasehold improvements
Property, Plant and Equipment [Line Items]
Property and equipment, gross	7,106	12,554
Furniture and office equipment
Property, Plant and Equipment [Line Items]
Property and equipment, gross	2,625	2,333
Other
Property, Plant and Equipment [Line Items]
Property and equipment, gross	$ 1,265	$ 502