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Nature of business (Details) - USD ($) $ in Thousands					1 Months Ended	12 Months Ended
Nature of business (Details) - USD ($) $ in Thousands	Jan. 04, 2024	Dec. 28, 2023	Mar. 04, 2022	Oct. 01, 2021	Jan. 31, 2024	Dec. 31, 2023	Dec. 31, 2022
Accumulated deficit						$ (261,182)	$ (393,512)
Cash, cash equivalents, and marketable debt securities						230,900
Subsequent Event. \| Over-Allotment Option
Net proceeds received	$ 93,500
Pfizer \| Option and license agreement
Upfront payment				$ 30,000
Novartis Pharma, AG \| Option and license agreement
Upfront payment			$ 54,000
Novartis Pharma, AG \| 2023 Novartis Collaboration Agreement
Upfront payment						$ 80,000
Proceeds from issuance of common stock		$ 20,000
Novartis Pharma, AG \| Forecast \| Novartis License and Collaboration Agreement
Upfront payment					$ 80,000