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Related party transactions (Details)	3 Months Ended
Related party transactions (Details)	Mar. 31, 2023 USD ($) individual	Mar. 31, 2022 USD ($)	Dec. 31, 2022 USD ($)
Related party transactions
Related party collaboration receivable	$ 328,000		$ 257,000
Dr. Sah \| Board and scientific advisory services
Related party transactions
Number of individuals providing services \| individual	1
Total amount of services received	$ 199,800
Dr. Sandrock \| Consulting and advisor services
Related party transactions
Total amount of services received		$ 60,000
Neurocrine \| Collaboration arrangement
Related party transactions
Related party collaboration receivable	$ 300,000