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Related party transactions (Details)	12 Months Ended
Related party transactions (Details)	Dec. 31, 2022 USD ($) item	Dec. 31, 2021 USD ($) item	Dec. 31, 2020 USD ($) item
Related party transactions
Related party collaboration receivable	$ 257,000	$ 732,000
Former Executives \| Board and scientific advisory services
Related party transactions
Number of individuals providing services \| item	2	2	2
Dr. Paul \| Board and scientific advisory services
Related party transactions
Total amount of services received			$ 200,000
Dr. Sah \| Board and scientific advisory services
Related party transactions
Total amount of services received	$ 500,000	$ 200,000	$ 400,000
Dr. Sandrock \| Consulting and advisor services
Related party transactions
Total amount of services received	60,000
Neurocrine \| Collaboration arrangement
Related party transactions
Related party collaboration receivable	$ 300,000