Commitments and contingencies - Other Agreements - (Details) $ in Millions	12 Months Ended
	Dec. 31, 2016 USD ($) multiple	Dec. 31, 2022 USD ($)	Dec. 31, 2021 USD ($)	Dec. 31, 2017 USD ($)
Loss Contingency [Abstract]
Contingency reserves for litigation liabilities		$ 0.0	$ 0.0
Non-profit organization agreement
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Maximum funding	$ 4.0
Funding multiple | multiple	2.6
Milestone payment liability				$ 1.0