Property and equipment, net (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Property, Plant and Equipment [Line Items]
Property and equipment, gross	$ 35,064	$ 37,833
Less: accumulated depreciation	(17,207)	(15,913)
Property and equipment, net	17,857	21,920
Depreciation expense	6,191	5,165	$ 3,817
Laboratory equipment
Property, Plant and Equipment [Line Items]
Property and equipment, gross	19,675	19,384
Leasehold improvements
Property, Plant and Equipment [Line Items]
Property and equipment, gross	12,554	15,695
Furniture and office equipment
Property, Plant and Equipment [Line Items]
Property and equipment, gross	2,333	2,524
Other
Property, Plant and Equipment [Line Items]
Property and equipment, gross	$ 502	$ 230