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Stock-based compensation (Details) $ / shares in Units, $ in Thousands	1 Months Ended			3 Months Ended		9 Months Ended
	Jul. 31, 2022 shares	Dec. 31, 2019 shares	Jan. 31, 2014 $ / shares shares	Sep. 30, 2022 USD ($) individual shares	Sep. 30, 2021 USD ($)	Sep. 30, 2022 USD ($) individual $ / shares shares	Sep. 30, 2021 USD ($)
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Stock-based compensation.				$ 2,189	$ 2,077	$ 6,998	$ 9,670
Stock options
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Stock-based compensation.				$ 1,357	1,372	$ 4,452	6,375
Stock options \| Inducement Awards
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Vesting period				4 years		4 years
Stock options \| Inducement Awards \| Vesting period, tranche one
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Vesting percentage				25.00%		25.00%
Stock options \| Inducement Awards \| Vesting period, tranche two
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Vesting period				36 months		36 months
Vesting percentage				75.00%		75.00%
Unvested restricted common stock units
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Stock-based compensation.				$ 748	651	$ 2,382	3,018
Vesting period						3 years
Restricted stock granted, original issued price (in dollars per share) \| $ / shares						$ 3.89
Performance based milestone awards
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Remaining number of shares authorized to be repurchased \| shares	72,647	58,823
Vesting period	2 years	3 years
Performance based milestone awards \| Maximum
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Stock-based compensation.				$ 100		$ 100
Founders restricted stock
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Restricted stock granted (in shares) \| shares			1,188,233
Restricted stock granted, original issued price (in dollars per share) \| $ / shares			$ 0.0425
Founders restricted stock \| Vesting period, tranche one
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Restricted stock granted (in shares) \| shares			835,292
Founders restricted stock \| Vesting period, tranche two
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Restricted stock granted (in shares) \| shares			352,941
Founders restricted stock \| Minimum \| Vesting period, tranche one
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Vesting period			1 year
Founders restricted stock \| Maximum \| Vesting period, tranche one
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Vesting period			4 years
Non-statutory stock options \| Inducement Awards
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Number of executives issued options \| individual				2		2
New stock options issued \| shares				276,000		276,000
Research and development
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Stock-based compensation.				$ 588	702	$ 2,170	3,409
General and administrative
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Stock-based compensation.				$ 1,601	$ 1,375	$ 4,828	$ 6,261