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Related party transactions (Details)	3 Months Ended		6 Months Ended
Related party transactions (Details)	Jun. 30, 2022 USD ($) individual	Jun. 30, 2021 USD ($) individual	Jun. 30, 2022 USD ($) individual	Jun. 30, 2021 USD ($) individual	Dec. 31, 2021 USD ($)
Related party transactions
Related party collaboration receivable	$ 151,000		$ 151,000		$ 732,000
Dr. Sah \| Board and scientific advisory services
Related party transactions
Number of individuals providing services \| individual	1,000	1,000	1,000	1,000
Total amount of services received	$ 82,425	$ 60,000	$ 92,325	$ 90,000
Dr. Sandrock \| Consulting and advisor services
Related party transactions
Total amount of services received			60,000
Neurocrine \| Collaboration arrangement
Related party transactions
Related party collaboration receivable	$ 200,000		$ 200,000