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Related party transactions (Details) $ in Thousands	3 Months Ended
Related party transactions (Details) $ in Thousands	Mar. 31, 2021 USD ($) individual	Mar. 31, 2020 USD ($) individual	Dec. 31, 2020 USD ($)
Related party transactions
Related party collaboration receivable	$ 4,253		$ 8,012
Dr. Sah \| Board and scientific advisory services
Related party transactions
Number of individuals providing services \| individual	1	1
Total amount of services received	$ 100	$ 100
Neurocrine Collaboration Agreement
Related party transactions
Related party collaboration receivable	$ 4,300