Commitments and contingencies - Other Agreements - (Details) $ in Millions	3 Months Ended	12 Months Ended
	Mar. 31, 2021 USD ($)	Dec. 31, 2019 USD ($)	Dec. 31, 2016 USD ($) multiple	Dec. 31, 2020 USD ($)	Dec. 31, 2017 USD ($)
Loss Contingency [Abstract]
Contingency reserves for litigation liabilities	$ 0.0			$ 0.0
Various contract research organizations and institutions
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Milestone payable upon achievement		$ 0.1
Various contract research organizations and institutions | Minimum
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Number of days written notice required by reporting entity to terminate agreement	30 days
Various contract research organizations and institutions | Maximum
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Number of days written notice required by reporting entity to terminate agreement	90 days
Non-profit organization agreement
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Maximum funding			$ 4.0
Funding multiple | multiple			2.6
Milestone payment liability					$ 1.0