Related party transactions (Details)	12 Months Ended
Dec. 31, 2020 USD ($) item	Dec. 31, 2019 USD ($) item	Dec. 31, 2018 USD ($) item
Related party transactions
Related party collaboration receivable	$ 8,012,000	$ 18,496,000
Former Executives \| Board and scientific advisory services
Related party transactions
Number of individuals providing services \| item	2	2	2
Dr. Paul \| Board and scientific advisory services
Related party transactions
Total amount of services received	$ 200,000	$ 200,000	$ 100,000
Dr. Sah \| Board and scientific advisory services
Related party transactions
Total amount of services received	400,000	400,000	$ 0
Neurocrine Collaboration Agreement
Related party transactions
Related party collaboration receivable	$ 8,000,000.0	$ 18,500,000

Amount, after allowance for credit loss, of right to consideration in exchange for good or service transferred to customer when right is conditioned on something other than passage of time, classified as current.

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 606
-SubTopic 10
-Section 45
-Paragraph 1
-URI http://asc.fasb.org/extlink&oid=121556615&loc=SL49130531-203044

Reference 2: http://www.xbrl.org/2003/role/disclosureRef
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Reference 3: http://www.xbrl.org/2003/role/disclosureRef
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-Name Accounting Standards Codification
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-Section 50
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Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 850
-SubTopic 10
-Section 50
-Paragraph 1
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