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Stock-based compensation - Unrecognized expense and weighted-average period (Details) - USD ($)
$ / shares in Units, $ in Millions
12 Months Ended
Dec. 31, 2020
Dec. 31, 2019
Dec. 31, 2018
Fair value assumptions      
Expected dividend yield 0.00%    
Employees and directors stock options      
Fair value assumptions      
Risk-free interest rate 1.00% 2.20% 2.80%
Expected term 6 years 6 years 6 years
Expected volatility 73.70% 74.70% 74.40%
Unvested stock options      
Options disclosures      
Unrecognized stock-based compensation expense $ 20.0    
Remaining weighted-average remaining vesting period 2 years 6 months    
Share-based Payment Arrangement, Employee      
Options disclosures      
Weighted average fair value of grants (in dollars per share) $ 7.64