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Related party transactions (Details)	3 Months Ended		6 Months Ended
Related party transactions (Details)	Jun. 30, 2020 USD ($) individual	Jun. 30, 2019 USD ($) individual	Jun. 30, 2020 USD ($) individual	Jun. 30, 2019 USD ($) individual	Dec. 31, 2019 USD ($)
Related party transactions
Related party collaboration receivable	$ 12,686,000		$ 12,686,000		$ 18,496,000
Investor \| Consulting and management services
Related party transactions
Number of individuals providing services \| individual	1	1	1	1
Total amount of services received	$ 0		$ 0
Accounts payable to related party	$ 0		$ 0
Former Executives \| Board and scientific advisory services
Related party transactions
Number of individuals providing services \| individual	2		2
Dr. Steven M Paul \| Board and scientific advisory services
Related party transactions
Expense recognized	$ 50,000	$ 100,000	$ 50,000	$ 100,000
Sah \| Board and scientific advisory services
Related party transactions
Expense recognized	100,000		200,000
Neurocrine \| Collaboration arrangement
Related party transactions
Related party collaboration receivable	$ 12,700,000		$ 12,700,000