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Commitments and contingencies - Other Agreements - (Details)
$ in Thousands
3 Months Ended 12 Months Ended
Mar. 31, 2020
USD ($)
Dec. 31, 2016
USD ($)
multiple
Dec. 31, 2019
USD ($)
Dec. 31, 2017
USD ($)
Loss Contingency [Abstract]        
Contingency reserves for litigation liabilities $ 0   $ 0  
Various contract research organizations and institutions        
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]        
Non-refundable upfront payment received     $ 100  
Various contract research organizations and institutions | Minimum        
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]        
Number of days written notice required by reporting entity to terminate agreement 30 days      
Various contract research organizations and institutions | Maximum        
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]        
Number of days written notice required by reporting entity to terminate agreement 90 days      
Non-profit organization agreement        
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]        
Maximum funding   $ 4,000    
Funding multiple | multiple   2.6    
Milestone payment liability       $ 1,000