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Commitments and contingencies - Termination of Agreement (Details) - Termination Agreement - Sanofi Genzyme
$ in Thousands
Jun. 14, 2019
USD ($)
item
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]  
AAV capsids to license | item 2
Number of non central nervous system | item 2
Up-front payment made $ 10,000
Milestone payment agreed to be paid $ 10,000
Period in which milestone payment will be made of filing of investigational new drug 15 days
Percentage of threshold sublicensing income agreed to be paid 50.00%
Unused in-kind services waived $ 400
Milestone payable upon achievement $ 15,000
Threshold number of capsids having exclusive options to evaluate for no consideration | item 4
Threshold additional number of capsids having options to evaluate for low six-figure payment per capsid | item 2
Threshold number of capsids that has right to obtain an exclusive license | item 2
Option exercise fee $ 1,000
Sales milestone  
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]  
Milestone payable upon achievement $ 20,000