Selected quarterly financial data (unaudited) (Tables)

12 Months Ended

Dec. 31, 2018

Selected quarterly financial data (unaudited)

Schedule of Quarterly Financial Information

	2018
	First		Second		Third		Fourth
	Quarter		Quarter		Quarter		Quarter		Total
	(amounts in thousands, except per share data)
Collaboration revenue	$	942	$	2,575	$	2,094	$	2,008	$	7,619
Total operating expenses		22,035		28,269		23,241		25,169		98,714
Loss from operations		(21,093)		(25,694)		(21,147)		(23,161)		(91,095)
Net loss		(19,926)		(25,541)		(20,289)		(22,532)		(88,288)
Net loss per share	$	(0.63)	$	(0.80)	$	(0.63)	$	(0.70)	$	(2.75)

	2017
	First		Second		Third		Fourth
	Quarter		Quarter		Quarter		Quarter		Total
	(amounts in thousands, except per share data)
Collaboration revenue	$	1,464	$	1,177	$	1,148	$	6,346	$	10,135
Total operating expenses		18,986		19,816		24,503		18,693		81,998
Loss from operations		(17,522)		(18,639)		(23,355)		(12,347)		(71,863)
Net loss		(16,648)		(18,876)		(23,346)		(11,828)		(70,698)
Net loss per share	$	(0.65)	$	(0.73)	$	(0.89)	$	(0.40)	$	(2.64)