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Commitments and contingencies - Significant Agreements - (Details) - Sanofi Genzyme - USD ($)
$ in Millions
1 Months Ended
Oct. 31, 2017
Feb. 28, 2015
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]    
Amount of reduction in milestone or royalty payments to be made by collaborative partner for each program specified   $ 10.0
Per Milestone, maximum milestone payments to be received from collaborative partner $ 540.0  
Regulatory approval milestone    
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]    
Aggregate maximum milestone payments to be received from collaborative partner 220.0  
Regulatory approval milestone | Minimum    
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]    
Per Milestone, maximum milestone payments to be received from collaborative partner 40.0  
Regulatory approval milestone | Maximum    
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]    
Per Milestone, maximum milestone payments to be received from collaborative partner 50.0  
Commercial Milestone    
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]    
Aggregate maximum milestone payments to be received from collaborative partner 320.0  
Commercial Milestone | Minimum    
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]    
Per Milestone, maximum milestone payments to be received from collaborative partner 50.0  
Commercial Milestone | Maximum    
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]    
Per Milestone, maximum milestone payments to be received from collaborative partner 100.0  
Collaborative Arrangement    
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]    
Non-refundable upfront payment received   65.0
Premium over fair value on temporary equity issued   5.0
Parkinson's Program | Regulatory and commercial milestone    
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]    
Milestone payments no longer receivable $ 105.0  
Spinal Muscular Atrophy Program    
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]    
Maximum potential in-kind services to be provided by collaborative partner   5.0
Option exercise payment required from collaborative partner for each program specified   30.0
Split Territory Program    
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]    
Option exercise payment required from collaborative partner for each program specified   $ 20.0
Redeemable Convertible Preferred Stock Series B | Collaborative Arrangement    
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]    
Temporary equity issued (in shares)   10,000,000
Temporary equity issued   $ 30.0
Fair value of temporary equity issued   25.0
Premium over fair value on temporary equity issued   $ 5.0