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Stock based compensation - Founder Awards - (Details) - USD ($)
$ / shares in Units, $ in Thousands
1 Months Ended 12 Months Ended
Jan. 01, 2017
Jan. 01, 2016
Jan. 31, 2014
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Oct. 31, 2015
2015 Employee Stock Purchase Plan              
Stock-based compensation       $ 6,310 $ 4,027 $ 425  
Research and development              
2015 Employee Stock Purchase Plan              
Stock-based compensation       4,296 3,218 297  
General and administrative              
2015 Employee Stock Purchase Plan              
Stock-based compensation       2,014 $ 809 $ 128  
Founders restricted stock              
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]              
Restricted stock granted (in shares)     1,188,233        
Restricted stock granted, original issued price (in dollars per share)     $ 0.0425        
2015 Employee Stock Purchase Plan              
Stock-based compensation       $ 1,100      
Vesting period, tranche one | Founders restricted stock              
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]              
Restricted stock granted (in shares)     835,292        
Vesting period, tranche two | Founders restricted stock              
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]              
Restricted stock granted (in shares)     352,941        
Minimum | Vesting period, tranche one | Founders restricted stock              
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]              
Vesting period     1 year        
Maximum | Vesting period, tranche one | Founders restricted stock              
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]              
Vesting period     4 years        
2015 Employee Stock Purchase Plan              
2015 Employee Stock Purchase Plan              
Number of shares authorized for stock-based compensation plan (in shares)             262,362
Additional shares added to stock option plan 267,658 267,492          
2015 Employee Stock Purchase Plan | Minimum              
2015 Employee Stock Purchase Plan              
Stock purchase plan payroll deduction percent             1.00%
2015 Employee Stock Purchase Plan | Maximum              
2015 Employee Stock Purchase Plan              
Stock purchase plan payroll deduction percent             10.00%