Selected quarterly financial data (unaudited)

12 Months Ended

Dec. 31, 2016

Quarterly Financial Information Disclosure [Abstract]

Selected Quarterly Financial Data

14. Selected quarterly financial data (unaudited)

The following table contains quarterly financial information for 2016 and 2015. The Company believes that the following information reflects all normal recurring adjustments necessary for a fair statement of the information for the periods presented. The operating results for any quarter are not necessarily indicative of results for any future period.

	2016
	First		Second		Third		Fourth
	Quarter		Quarter		Quarter		Quarter		Total
	(in thousands, except per share data)
Collaboration revenue	$	4,830	$	3,720	$	3,308	$	2,362	$	14,220
Total operating expenses		12,297		13,338		13,679		16,205		55,519
Loss from operations		(7,467)		(9,618)		(10,371)		(13,843)		(41,299)
Net loss attributable to common shareholders		(7,188)		(9,335)		(8,996)		(14,674)		(40,193)
Net loss per share applicable to common stockholders – basic and diluted	$	(0.29)	$	(0.37)	$	(0.35)	$	(0.57)	$	(1.59)

	2015
	First		Second		Third		Fourth
	Quarter		Quarter		Quarter		Quarter		Total
	(in thousands, except per share data)
Collaboration revenue	$	2,576	$	4,884	$	4,937	$	4,937	$	17,334
Total operating expenses		7,404		8,851		8,956		12,377		37,588
Loss from operations		(4,828)		(3,967)		(4,019)		(7,440)		(20,254)
Net loss attributable to common shareholders		(15,813)		(6,746)		(6,914)		(8,817)		(38,290)
Net loss per share applicable to common stockholders – basic and diluted	$	(15.81)	$	(5.80)	$	(5.25)	$	(0.67)	$	(9.14)