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Related party transactions (Details) - USD ($)
3 Months Ended 9 Months Ended
Sep. 30, 2016
Sep. 30, 2015
Sep. 30, 2016
Sep. 30, 2015
Investor        
Related Party Transaction [Line Items]        
Accounts payable to related party $ 19,000   $ 19,000  
Investor | Consulting and management services        
Related Party Transaction [Line Items]        
Total amount of services received 19,000 $ 6,000 35,000 $ 115,000
Genzyme | Collaboration arrangement        
Related Party Transaction [Line Items]        
Revenue recognized 3,308,000 4,937,000 11,858,000 12,397,000
Expense recognized $ 236,000 $ 125,000 $ 989,000 $ 2,190,000