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Stock based compensation - 2014 Stock Option and Grant Plan - (Details)
1 Months Ended 3 Months Ended 9 Months Ended
Jan. 01, 2016
shares
Jan. 31, 2014
$ / shares
shares
Sep. 30, 2016
USD ($)
shares
Sep. 30, 2015
USD ($)
Sep. 30, 2016
USD ($)
shares
Sep. 30, 2015
USD ($)
Oct. 31, 2015
shares
Aug. 31, 2015
shares
Apr. 30, 2015
shares
Aug. 31, 2014
shares
Apr. 30, 2014
shares
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                      
Stock-based compensation | $     $ 1,789,000 $ 857,000 $ 4,529,000 $ 2,061,000          
Stock options granted (in shares)         896,610            
2014 Stock Option and Grant Plan (2014 Plan)                      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                      
Number of shares authorized for stock-based compensation plan (in shares)   823,529         2,998,823 2,669,411 2,047,058 2,000,000 1,411,764
2015 Employee Stock Purchase Plan                      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                      
Shares available for future issuance (in shares)     267,492   267,492   262,362        
2015 Stock Option Plan                      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                      
Shares available for future issuance (in shares)     1,879,606   1,879,606   1,311,812        
Percentage limit of issued and outstanding shares upto which additional shares may be issued         4.00            
Additional shares added to stock option plan 1,069,971                    
Unvested restricted stock awards                      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                      
Unrecognized stock-based compensation expense | $     $ 11,808,000   $ 11,808,000            
Employees restricted stock                      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                      
Stock-based compensation | $     128,000   393,000 134,000          
Non-employee consultants restricted stock                      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                      
Stock-based compensation | $         1,871,000 457,000          
Performance based milestone awards                      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                      
Stock-based compensation | $     151,000   960,000            
Founders restricted stock                      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                      
Stock-based compensation | $         0            
Restricted stock granted (in shares)   1,188,233                  
Restricted stock granted, original issued price (in dollars per share) | $ / shares   $ 0.0425                  
Founders restricted stock | Vesting period, tranche one                      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                      
Restricted stock granted (in shares)   835,292                  
Founders restricted stock | Vesting period, tranche two                      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                      
Restricted stock granted (in shares)   352,941                  
Founders restricted stock | Minimum | Vesting period, tranche one                      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                      
Vesting period   1 year                  
Founders restricted stock | Maximum | Vesting period, tranche one                      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                      
Vesting period   4 years                  
Employees and directors stock options                      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                      
Stock-based compensation | $     $ 914,000   $ 2,155,000 215,000          
Employees and directors stock options | 2015 Stock Option and Incentive Plan                      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                      
Stock options granted (in shares)     84,600                
Employees and directors stock options | 2015 Stock Option Plan                      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                      
Stock options granted (in shares)         888,110            
Non-employees stock options                      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                      
Stock-based compensation | $     $ 56,000 $ 49,000 $ 110,000 $ 263,000