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Related party transactions (Details) - USD ($)	1 Months Ended	12 Months Ended
Related party transactions (Details) - USD ($)	Jan. 31, 2014	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Related Party Transaction [Line Items]
Fair value of common stock issued as partial compensation for consulting and management services			$ 252,000
Investor
Related Party Transaction [Line Items]
Total amount of services received		$ 122,000		$ 2,379,000
Investor \| Consulting and management services
Related Party Transaction [Line Items]
Common stock issued as partial compensation for consulting and management services (in shares)	470,589
Fair value of common stock issued as partial compensation for consulting and management services	$ 238,000
Total amount of services received			$ 1,280,000
Accounts payable to related party		7,000
Genzyme \| Collaboration arrangement
Related Party Transaction [Line Items]
Revenue recognized		17,334,000
Expense recognized		$ 2,316,000