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Summary of significant accounting policies - Net loss per share - (Details) - USD ($)
$ in Thousands
3 Months Ended 6 Months Ended 12 Months Ended
Dec. 31, 2015
Sep. 30, 2015
Jun. 30, 2015
Mar. 31, 2015
Dec. 31, 2014
Sep. 30, 2014
Jun. 30, 2014
Mar. 31, 2014
Dec. 31, 2013
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2013
Earnings Per Share, Pro Forma [Abstract]                        
Antidilutive Securities Excluded from Computation of Earnings Per Share (in common stock equivalent shares)                   4,723,719 8,461,169 0
Add: Changes in fair value of preferred stock tranche liability                   $ 9,750 $ 1,949  
Net loss attributable to common stockholders $ (8,817) $ (6,914) $ (6,746) $ (15,813) $ (5,197) $ (4,411) $ (4,864) $ (3,211) $ (3,833) (38,290) (17,683)  
Accretion of redeemable convertible preferred stock to redemption value                   (7,373) $ (1,366)  
Add: Accrued dividends on temporary equity                   $ 1,245    
Weighted average number of common shares outstanding, basic and diluted (in shares)                 2,352 4,191,210 635,448  
Redeemable convertible preferrred stock                        
Earnings Per Share, Pro Forma [Abstract]                        
Antidilutive Securities Excluded from Computation of Earnings Per Share (in common stock equivalent shares)                     5,882,352 0
Unvested restricted common stock                        
Earnings Per Share, Pro Forma [Abstract]                        
Antidilutive Securities Excluded from Computation of Earnings Per Share (in common stock equivalent shares)                   1,818,261 2,578,817 0
Outstanding stock options                        
Earnings Per Share, Pro Forma [Abstract]                        
Antidilutive Securities Excluded from Computation of Earnings Per Share (in common stock equivalent shares)                   2,905,458   0