X0306 4 2016-06-13 0 0001232524 Jazz Pharmaceuticals plc JAZZ 0001639637 Smith Karen L. CONNAUGHT HOUSE, 1 BURLINGTON RD, FL. 4 DUBLIN 4 L2 IRELAND 0 1 0 0 Global Head of R&D and CMO Ordinary Shares 2016-06-13 4 P 0 557.0 149.6142 A 12994 D This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person. Reflects purchases of ordinary shares executed in multiple transactions at prices ranging from $149.54 to $150.28. The price reported reflects the weighted average purchase price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the purchases were made. Includes 38 ordinary shares acquired under a Section 423 Employee Stock Purchase Plan on May 31, 2016. By: Valerie Pierce as attorney in fact For: Karen Lesley Smith 2016-06-15