X0306 4 2020-05-18 0 0001001233 SANGAMO THERAPEUTICS, INC SGMO 0001639637 Smith Karen L. C/O SANGAMO THERAPEAUTICS, INC. 7000 MARINA BLVD BRISBANE CA 94405 1 0 0 0 Common Stock 2020-05-18 4 A 0 2500 0.00 A 10000 D Stock Option (Right to Buy) 10.46 2020-05-18 4 A 0 15000 0.00 A 2030-05-17 Common Stock 15000 15000 D Represents shares of common stock issuable upon settlement of restricted stock units ("RSUs"). The RSUs will fully vest on the earlier of (x) May 18, 2021, (the first anniversary of the date of grant) or (y) the day prior to the 2021 annual stockholders meeting, subject to the Reporting Person's continued service on the Issuer's Board of Directors through such date. Includes 3,333 shares of common stock issuable upon settlement of RSUs granted to the Reporting Person on June 26, 2018 representing two remaining vesting tranches from such RSU grant. Such RSUs vest with respect to 1,666 shares on June 26, 2020 and 1,667 shares on June 26, 2021, subject to the Reporting Person's continued service on the Issuer's Board of Directors through such dates. Each option is immediately exercisable for all option shares, but shares purchased under the option are subject to certain repurchase rights by the Issuer upon cessation of the Reporting Person's service on the Board of the Directors of the Issuer. The shares subject to the option vest in 12 successive equal monthly installments upon the Reporting Person's completion of each month of Board service over the 12-month period measured from the grant date. /s/ Matthew Colvin, Attorney-in-Fact for Karen L. Smith 2020-05-20