X0306 4 2019-06-10 0 0001001233 SANGAMO THERAPEUTICS, INC SGMO 0001639637 Smith Karen L. C/O SANGAMO THERAPEAUTICS, INC. POINT RICHMOND TECH CTR, 501 CANAL BLVD. RICHMOND CA 94804 1 0 0 0 Common Stock 2019-06-10 4 A 0 2500 0.00 A 7500 D Stock Option (Right to Buy) 9.38 2019-06-10 4 A 0 15000 0.00 A 2029-06-09 Common Stock 15000 15000 D Represents shares of common stock issuable upon settlement of restricted stock units ("RSUs"). The RSUs will fully vest on the earlier of (x) June 10, 2020 (the first anniversary of the date of grant) or (y) the day prior to the 2020 annual stockholders meeting, subject to the Reporting Person's continued service on the Issuer's Board of Directors through such date. Includes 5,000 shares of common stock issuable upon settlement of restricted stock units ("RSUs") granted to the Reporting Person on June 26, 2018. The RSUs will vest with respect to 1/3rd of the shares in three equal annual installments over the three-year period measured from the date of grant, subject to the Reporting Person's continued service on the Issuer's Board of Directors through such date. Each option is immediately exercisable for all option shares, but shares purchased under the option are subject to certain repurchase rights by the Issuer upon cessation of the Reporting Person's service on the Board of the Directors of the Issuer. The shares subject to the option vest in 12 successive equal monthly installments upon the Reporting Person's completion of each month of Board service over the 12-month period measured from the grant date. /s/ Denise Winn, Attorney-in-Fact for Karen L. Smith 2019-06-12