X0306 4 2018-02-13 1 0001365216 Sucampo Pharmaceuticals, Inc. SCMP 0001639637 Smith Karen L. 805 KING FARM BLVD, SUITE 550 ROCKVILLE MD 20850 1 0 0 0 Director Stock Option (right to buy) 10.95 2018-02-13 4 D 0 30000 7.05 D 2027-07-15 Common Stock 30000 0 D This option was cancelled and converted into the right to receive in cash the amount per share by which $18.00 exceeds the exercise price of the option, subject to any applicable tax witholdings (such amount, the "Option Spread"), upon the effective time of the merger of Sun Acquisition Co.with and into Sucampo Pharmaceuticals, Inc. pursuant to the Merger Agreement. The Option Spread for the unvested portion of the option, if any, will be paid in accordance with the schedule described in the Merger Agreement. /s/ Karen Smith 2018-02-13