X0306 4 2021-10-15 0 0001626878 XBiotech Inc. XBIT 0001639078 SIMARD JOHN 5217 WINNEBAGO LANE AUSTIN TX 78744 1 1 1 0 Chief Executive Officer Common Stock 2021-10-15 4 S 0 17000 13.3218 D 3856166 D Common Stock 2021-10-18 4 S 0 33000 13.0683 D 3823166 D The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions. The reporting person undertakes to provide to XBIT, any security holder of XBIT, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote. John Simard, CEO Chairman of XBiotech, Inc., adopted a stock trading plan. He sold total of 50,000 common stock on the open market as part of this 10B5-1 trading plan. /s/ Queena Han under Power of Attorney for John Simard 2022-02-15