X0306 4 2019-12-06 0 0001626878 XBiotech Inc. XBIT 0001639078 SIMARD JOHN 5217 WINNEBAGO LANE AUSTIN TX 78744 1 1 1 0 Chief Executive Officer Stock Option 11.12 2019-12-06 4 M 0 1000000 11.12 A 2020-06-11 2029-12-11 Common Stock 1000000 2625000 D On December 6, 2019 (the Grant Date) John Simard was granted nonstatutory stock options under the Company's 2015 Equity Incentive Plan to purchase shares of the Company's Common Stock at an exercise price equal to the closing price of the Company's common stock, as reported by the Nasdaq Stock Market, on the Grant Date. The options will vest in two equal installments on the six-month anniversary and the first anniversary of the Grant Date. /s/ Ashley Otero under Power of Attorney for John Simard 2019-12-11