X0306 4 2017-03-22 0001434647 KEMPHARM, INC KMPH 0001638366 Mickle Christal M M C/O KEMPHARM, INC. 2500 CROSSPARK ROAD, SUITE E126 CORALVILLE IA 52241 1 1 VP, Operations & Product Dvlp. Common Stock 2017-03-22 4 P 0 2000 4.09950 A 9050 I By Mickle Investments LLC Common Stock 2017-01-27 5 G 0 144905 0 A 1526081 I By spouse Common Stock 2017-01-27 5 G 0 71262 0 A 1597343 I By spouse Common Stock 2017-01-27 5 G 0 144905 0 D 85907 I By Travis C Mickle & Christal M.M. Mickle TRS UA 4-30-09 TCM Family Trust, co-trustee with spouse Common Stock 2017-01-27 5 G 0 71262 0 D 159550 I By Travis C Mickle & Christal M.M. Mickle TRS UA 4-30-09 Mickle Family Trust, co-trustee with spouse Common Stock 33614 D Common Stock 157197 I By Travis C. Mickle 2015 Dynasty Trust dtd 7/21/15, as trustee Common Stock 243880 I By Christal M.M. Mickle 2015 Gift Trust, by spouse as trustee Common Stock 100604 D The Reporting Person and her spouse are the managing members of Mickle Investments LLC. Held jointly with spouse. /s/ Christal M.M. Mickle 2017-03-24