X0306 4 2019-05-10 0001434647 KEMPHARM, INC KMPH 0001638364 Plooster Matthew R C/O KEMPHARM, INC. 1180 CELEBRATION BOULEVARD, SUITE 103 CELEBRATION FL 34747 1 Common Stock 2019-05-10 4 A 0 8487 0 A 16655 D Common Stock 1117 I By TD Ameritrade Clearing Inc. Custodian FBO Matthew Ryan Plooster Roth IRA, as trustee Grant to the Reporting Person of a fully vested restricted stock award ("RSA") under the Issuer's 2014 Equity Incentive Plan. The RSA was granted to the Reporting Person in lieu of the quarterly cash compensation payable to the Reporting Person pursuant to the Issuer's Third Amended and Restated Non-Employee Director Compensation Policy. /s/ Timothy J. Sangiovanni, Attorney-in-Fact for Matthew R. Plooster 2019-05-14