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Commitments and Contingencies - Pfizer License Agreement (Details) - USD ($)
Dec. 31, 2018
Dec. 31, 2017
Commitments and Contingencies    
No liabilities were recorded related to the license agreement $ 11,920,000 $ 15,076,000
Pfizer, Inc. | License Agreement    
Commitments and Contingencies    
No liabilities were recorded related to the license agreement $ 0