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Condensed Statements of Comprehensive Loss - USD ($)
3 Months Ended 9 Months Ended
Sep. 30, 2018
Sep. 30, 2017
Sep. 30, 2018
Sep. 30, 2017
Operating expenses:        
General and administrative $ 2,364,000 $ 2,050,000 $ 7,025,000 $ 8,951,000
Research and development 3,542,000 6,489,000 12,479,000 17,606,000
Total operating expenses 5,906,000 8,539,000 19,504,000 26,557,000
Loss from operations (5,906,000) (8,539,000) (19,504,000) (26,557,000)
Interest expense, net (172,000) (132,000) (476,000) (107,000)
Other expense (1,000)   (1,000) (5,000)
Loss before income taxes (6,079,000) (8,671,000) (19,981,000) (26,669,000)
Provision (benefit) for income taxes 0 0 0 0
Net loss (6,079,000) (8,671,000) (19,981,000) (26,669,000)
Other comprehensive loss, net of tax 0 0 0 0
Comprehensive loss $ (6,079,000) $ (8,671,000) $ (19,981,000) $ (26,669,000)
Net loss per share:        
Basic and diluted (Note 9) $ (0.43) $ (0.82) $ (1.46) $ (2.60)
Number of shares used in per share calculations:        
Basic and diluted 14,259,691 10,623,601 13,650,556 10,253,437