X0306 4 2020-04-29 0 0001637761 SeaSpine Holdings Corp SPNE 0001187576 CARUSO RICHARD E 311 C ENTERPRISE DRIVE PLAINSBORO NJ 08536 0 0 1 0 Common Stock 2020-04-29 4 X 0 4921 9.43 A 20378 D Common Stock 2020-04-29 4 S 0 4921 10.5587 D 15457 D Common Stock 1997068 I By Tru St Partnership LP Common Stock 24382 I By The Uncommon Individual Foundation Common Stock 7779 I By Provco Leasing Corporation Stock Option (Right-to-Buy) 9.43 2020-04-29 4 X 0 4921 0 D 2015-07-01 2020-05-15 Common Stock 4921 0 D The reporting person disclaims beneficial ownership of these securities, and this report shall not be deemed an admission that the reporting person is the beneficial owner of such securities for purposes of Section 16 or for any other purpose. Tru St Partnership, LP ("Tru St") may be deemed the beneficial owner of 1,997,068 shares of common stock. Dr. Caruso is the Chairman Emeritus of Provco Leasing Corporation ("Provco Leasing"). Provco Leasing is the corporate general partner of Tru St Partnership LP. Provco Leasing owns 7,779 shares of common stock directly and is the beneficial owner of 2,004,847 shares of common stock. The Uncommon Individual Foundation is the beneficial owner of 24,382 shares of common stock as of December 31, 2018. Dr. Caruso is the founder and chief executive officer of The Uncommon Individual Foundation. At the quarterly board meeting of The Uncommon Individual Foundation and has been given the honorary title of Chairman Emeritus. /s/ Gary DiLella, Attorney-in-Fact for Richard E. Caruso 2020-05-01