X0202 SCHEDULE 13G/A 0001104659-25-116660 0001617201 XXXXXXXX LIVE 1 Class A Common Stock, par value $0.0001 per share 06/30/2026 0001637715 OnKure Therapeutics, Inc. 68277Q105 6707 WINCHESTER CIRCLE SUITE 400 BOULDER CO 80301 Rule 13d-1(c) Prosight Management, LP b DE 0.00 978992.00 0.00 978992.00 978992.00 2.4 IA The figure in Item 11 is based upon 40,395,480 shares of Common Stock of the Issuer outstanding as of May 4th, 2026, as disclosed in the Issuer's Form 10-Q, filed with the SEC on May 5, 2026. Prosight Fund, LP b DE 0.00 45771.00 0.00 45771.00 45771.00 0.1 PN The figure in Item 11 is based upon 40,395,480 shares of Common Stock of the Issuer outstanding as of May 4th, 2026, as disclosed in the Issuer's Form 10-Q, filed with the SEC on May 5, 2026. Prosight Plus Fund, LP b DE 0.00 219725.00 0.00 219725.00 219725.00 0.5 PN The figure in Item 11 is based upon 40,395,480 shares of Common Stock of the Issuer outstanding as of May 4th, 2026, as disclosed in the Issuer's Form 10-Q, filed with the SEC on May 5, 2026. Prosight Partners, LLC b DE 0.00 978992.00 0.00 978992.00 978992.00 2.4 OO The figure in Item 11 is based upon 40,395,480 shares of Common Stock of the Issuer outstanding as of May 4th, 2026, as disclosed in the Issuer's Form 10-Q, filed with the SEC on May 5, 2026. W. Lawrence Hawkins b X1 0.00 978992.00 0.00 978992.00 978992.00 2.4 HC IN The figure in Item 11 is based upon 40,395,480 shares of Common Stock of the Issuer outstanding as of May 4th, 2026, as disclosed in the Issuer's Form 10-Q, filed with the SEC on May 5, 2026. OnKure Therapeutics, Inc. 6707 WINCHESTER CIRCLE, SUITE 400, BOULDER, COLORADO, 80301 This statement is jointly filed by and on behalf of each of Prosight Management, LP, a Delaware limited partnership ("Prosight Management"), Prosight Fund, LP, a Delaware limited partnership ("Prosight Fund"), Prosight Plus Fund, LP, a Delaware limited partnership ("Prosight Plus Fund"), Prosight Partners, LLC, a Delaware limited liability company ("Prosight Partners"), and W. Lawrence Hawkins (collectively referred herein as the "Reporting Persons"). Prosight Management is the general partner and investment manager of, and may be deemed to indirectly beneficially own securities owned by, Prosight Fund and Prosight Plus Fund. Prosight Management is a sub-advisor for certain separate managed accounts (collectively, the "Managed Accounts") and may be deemed to indirectly beneficially own securities owned by the Managed Accounts. Prosight Partners is the general partner of, and may be deemed to beneficially own, securities beneficially owned by Prosight Management. Mr. Hawkins is the sole manager of, and may be deemed to beneficially own securities beneficially owned by, Prosight Partners. Prosight Fund, Prosight Plus Fund, and the Managed Accounts are the record and direct beneficial owner of the securities of the Issuer covered by this statement. Prosight Fund disclaims beneficial ownership of the securities of the Issuer held by each of the Managed Accounts and Prosight Plus Fund. Prosight Plus Fund disclaims beneficial ownership of the securities of the Issuer held by each of the Managed Accounts and Prosight Fund. Each Reporting Person declares that neither the filing of this statement nor anything herein shall be construed as an admission that such person is, for the purposes of Section 13(d) or 13(g) of the Securities Exchange Act of 1934, as amended (the "Act") or any other purpose, the beneficial owner of any securities covered by this statement. Each Reporting Person may be deemed to be a member of a group with respect to the Issuer or securities of the Issuer for the purpose of Section 13(d) or 13(g) of the Act. Each of the Reporting Persons declares that neither the filing of this statement nor anything herein shall be construed as an admission that such person is, for the purpose of Section 13(d) or 13(g) of the Act or any other purpose, (i) acting (or has agreed or is agreeing to act together with any other person) as a partnership, limited partnership, syndicate, or other group for the purpose of acquiring, holding, or disposing of securities of the Issuer or otherwise with respect to the Issuer or any securities of the Issuer or (ii) a member of any group with respect to the Issuer or any securities of the Issuer. The address of the principal business office of each of the Reporting Persons is c/o Prosight Management, LP, 5956 Sherry Lane, Suite 1365, Dallas, Texas 75225. See Item 4 on the cover page(s) hereto. Y See Item 9 on the cover pages hereto. See Item 11 on the cover pages hereto. See Item 5 on the cover pages hereto. See Item 6 on the cover pages hereto. See Item 7 on the cover pages hereto. See Item 8 on the cover pages hereto. Y Y Y Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11. Prosight Management, LP W. Lawrence Hawkins 08/10/2026 Prosight Fund, LP W. Lawrence Hawkins 08/10/2026 Prosight Plus Fund, LP W. Lawrence Hawkins 08/10/2026 Prosight Partners, LLC W. Lawrence Hawkins 08/10/2026 W. Lawrence Hawkins W. Lawrence Hawkins 08/10/2026