X0306 4 2022-08-29 0 0001637715 Reneo Pharmaceuticals, Inc. RPHM 0001854179 Cruse Michael C/O RENEO PHARMACEUTICALS, INC. 18575 JAMBOREE ROAD, SUITE 275-S IRVINE CA 92612 0 1 0 0 Chief Operating Officer Common Stock 2022-08-29 4 P 0 83 3.24 A 30783 D Common Stock 2022-08-29 4 P 0 1140 3.24 A 1140 I by Trust Common Stock 2022-08-30 4 P 0 975 3.16 A 31758 D Common Stock 2022-08-30 4 P 0 1845 3.1938 A 2985 I by Trust Common Stock 2022-08-31 4 P 0 3212 3.209 A 6197 I by Trust Includes 1,600 shares acquired under the Issuer's 2021 Employee Stock Purchase Plan on June 8, 2022. By Michael P. Cruse and Thu Anh Thuy Cruse, Trustees of The Cruse Family Revocable Living Trust. The weighted average purchase price for the transaction was $3.16. The shares were purchased at a range of prices between $3.11 and $3.19. Upon request by the SEC staff, the Issuer, or any security holder of the Issuer, full information regarding the number of shares purchased at each separate price will be provided. The weighted average purchase price for the transaction was $3.1938. The shares were purchased at a range of prices between $3.16 and $3.25. Upon request by the SEC staff, the Issuer, or any security holder of the Issuer, full information regarding the number of shares purchased at each separate price will be provided. The weighted average purchase price for the transaction was $3.209. The shares were purchased at a range of prices between $3.19 and $3.29. Upon request by the SEC staff, the Issuer, or any security holder of the Issuer, full information regarding the number of shares purchased at each separate price will be provided. /s/ Michael Cruse 2022-08-31