X0206 3 2022-03-31 0 0001637715 Reneo Pharmaceuticals, Inc. RPHM 0001919598 Lam Jennifer C/O RENEO PHARMACEUTICALS, INC. 18575 JAMBOREE ROAD, SUITE 275-S IRVINE CA 92612 0 1 0 0 VP of Finance & Administration Common Stock 15000 D Stock Option (right to buy) 8.66 2031-09-09 Common Stock 50000 D Stock Option (right to buy) 6.69 2031-12-09 Common Stock 35000 D Stock Option (right to buy) 4.58 2032-03-01 Common Stock 10000 D 1/4 of the shares vest and become exercisable on September 10, 2022, and the remaining shares vest in equal monthly installments over the subsequent 36 months, subject to Reporting Person's Continuous Service (as defined in the 2021 Equity Incentive Plan) as of each such vesting date. The shares vest in a series of 48 successive equal monthly installments measured from December 10, 2021, subject to Reporting Person's Continuous Service (as defined in the 2021 Equity Incentive Plan) as of each such vesting date. The shares vest in a series of 48 successive equal monthly installments measured from March 2, 2022, subject to Reporting Person's Continuous Service (as defined in the 2021 Equity Incentive Plan) as of each such vesting date. /s/ Jennifer Lam 2022-04-05